Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Physical and functional interaction among Irf8 enhancers during dendritic cell differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE239952 | GEO | 2024/04/24

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Cis-regulation between Irf8 enhancers during cDC1 development

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-03-14 | GSE218992 | GEO

IRF8-induced monocyte differentiation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-24 | E-GEOD-38825 | biostudies-arrayexpress

IRF8-induced monocyte differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-01-24 | GSE38825 | GEO

CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-02-26 | E-GEOD-60240 | biostudies-arrayexpress

KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-27 | E-GEOD-53093 | biostudies-arrayexpress

Physical and functional CSL-p53 interactions underlie control of cancer stromal cell evolution

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-08-24 | E-GEOD-65474 | biostudies-arrayexpress

Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.

Project description:Beta-catenin signaling has recently been tied to the emergence of tolerogenic dendritic cells (DCs). In this article, we demonstrate a novel role for beta-catenin in directing DC subset development through IFN regulatory factor 8 (IRF8) activation. We found that splenic DC precursors express beta-catenin, and DCs from mice with CD11c-specific constitutive beta-catenin activation upregulated IRF8 through targeting of the Irf8 promoter, leading to in vivo expansion of IRF8-dependent CD8a+, plasmacytoid, and CD103+ CD11b2 DCs. beta-catenin–stabilized CD8a+ DCs secreted elevated IL-12 upon in vitro microbial stimulation, and pharmacological beta-catenin inhibition blocked this response in wild-type cells. Upon infections with Toxoplasma gondii and vaccinia virus, mice with stabilized DC beta-catenin displayed abnormally high Th1 and CD8+ T lymphocyte responses, respectively. Collectively, these results reveal a novel and unexpected function for beta-catenin in programming DC differentiation toward subsets that orchestrate proinflammatory immunity to infection.

| S-EPMC4333072 | biostudies-other

Transcription factor Etv6 controls functional differentiation of cross-presenting classical dendritic cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-08-03 | GSE106408 | GEO

Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-08 | GSE179613 | GEO

Extensive Functional Redundancy of Mammalian Enhancers

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-01-01 | GSE93730 | GEO