Transcriptomics

Dataset Information

0

Single-cell transcriptomics of pediatric Burkitt lymphoma


ABSTRACT: Burkitt lymphoma (BL) is the most frequent B-cell lymphoma in pediatric patients. While most patients are currently cured, a fraction of them are resistant to therapy. In order to investigate BL heterogeneity and the features distinguishing the non-responders (NR) to therapy, we analyzed pediatric EBV-negative BL specimens collected at diagnosis by single-cell (sc)-transcriptomics. Analysis of the non-tumor component revealed a predominance of immune cell infiltrates and a small representation of fibroblasts that was enriched in NR. Tumor cells displayed patient-specific features, as well as subpopulations that were common to most patients and expressed transcripts related to cell cycle, signaling pathways and cell-of-origin signatures.

ORGANISM(S): Homo sapiens

PROVIDER: GSE240252 | GEO | 2024/10/24

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-08-16 | GSE35163 | GEO
2012-08-16 | E-GEOD-35163 | biostudies-arrayexpress
2013-06-01 | GSE42637 | GEO
2013-06-01 | E-GEOD-42637 | biostudies-arrayexpress
2017-01-02 | PXD004181 | Pride
2015-09-30 | GSE41865 | GEO
2012-08-14 | GSE35219 | GEO
2021-12-31 | GSE159303 | GEO
2023-12-19 | GSE198253 | GEO
2011-07-17 | E-GEOD-22420 | biostudies-arrayexpress