Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Aging and senescence-associated signatures of aged kidney glomerular cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE240375 | GEO | 2024/09/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Aging and senescence-associated signatures of aged kidney glomerular cells [scRNA-seq]

Project description:The kidney governs many physiological factors of the body, and the glomerulus is its core filtration unit. Glomeruli comprise of less than 1.5% of the kidney’s volume and thus are underrepresented in many analyses of the kidney, and require particular isolation methods. Aging is a major risk factor for kidney disease, yet despite the importance of proper glomerular function, we have limited knowledge of the changes that glomerular cells undergo during aging. Here we interrogate the aged mouse kidney, glomerulus and glomerular cells using various approaches, including single cell RNA sequencing (scRNA-Seq), to identify age and senescence associated changes at the tissue and cellular level. We show that the aged kidney and glomerulus undergo structural changes, including increased fibrosis, glomerulonephritis and expression of injury and senescence-associated markers. Lastly, we utilized our method for high-throughput analysis of mouse glomeruli to characterize cell-specific and age-related changes in glomerular cells. This analysis revealed a senescence-associated phenotype in aged mesangial cells, and emphasized the potential importance of mesangial cells and macrophages in this niche. Our study provides insights into the molecular and cellular changes of the aging glomerulus that suggest therapeutic targets for age-related renal dysfunction.

2024-09-01 | GSE240374 | GEO

Aging and senescence-associated signatures of aged kidney glomerular cells [bulk RNA-seq]

2024-09-01 | GSE240373 | GEO

Senescence associated gene signatures

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-03-03 | GSE197604 | GEO

Identification of aging-associated gene expression signatures that precede intestinal tumorigenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-05-03 | GSE80984 | GEO

Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-10-23 | E-GEOD-58006 | biostudies-arrayexpress

Dynamic enhancer interactome promotes senescence and aging

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-01-18 | GSE253618 | GEO

Replicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-03-26 | E-GEOD-59979 | biostudies-arrayexpress

Microsensor and transcriptome signatures of oxygen depletion in biofilms associated with chronic wounds

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-24 | E-GEOD-75361 | biostudies-arrayexpress

Whole transcriptome analysis for kidney aging in mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-11 | GSE154223 | GEO

Impact Of Age-Associated Increase In 2'-O-Methylation Of miRNAs On Aging And Neurodegeneration In Drosophila

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-01 | E-GEOD-52963 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data