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Stranded bulk Illumina RNASeq of human mammary tumors before and after neoadjuvant chemotherapy treatment

ABSTRACT: This study is designed to find a reliable marker enabling to predict the response to treatment in patients with early breast cancers treated by neoadjuvant chemotherapy. This marker would allow on one hand to select more homogeneous patient cohorts requiring treatment escalation strategies, and on the other hand reduce the burden of toxicity (both treatment-related and financial) for the patients that will already derive high benefit from the conventional treatments. In this study, gene expression profiles were measured and correlated with the clinical response to neoadjuvant chemotherapy and other features like the epithelial to mesenchymal transition and the tumor immune cell infiltration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE240671 | GEO | 2024/02/28

REPOSITORIES: GEO

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