Transcriptomics

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SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells


ABSTRACT: Using CRISPR/Cas9 dropout screening, we identified superoxide dismutase-1 (SOD1) as a genetic dependency specific to PPM1D-mutant leukemia cells. We found that the mutant cells exhibited a compromised response to oxidative stress that can be rescued with SOD1 inhibitors. PPM1D-mutant fcells also exhibit significant genomic instability, highlighting the essential role of SOD1 in safeguarding against oxidative stress and DNA damage.

ORGANISM(S): Homo sapiens

PROVIDER: GSE240874 | GEO | 2024/04/15

REPOSITORIES: GEO

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