Transcriptomics

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Effect of NIBR-LTSi treatment on gene expression in mouse intestinal organoids


ABSTRACT: The YAP/Hippo pathway is a key regulator of organ growth and size regulation and is involved in safeguarding multiple tissue stem cell compartments. LATS kinases phosphorylate and thereby inactivate YAP, thus representing a potential direct drug target for promoting tissue regeneration. We report on the gene expression changes associated with YAP activation by the selective small molecule LATS kinase inhibitor NIBR-LTSi in mouse intestinal organoids. We show that, LATS-LTSi activates YAP signalling, promotes proliferation, induces a regenerative phenotype and blocks differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE240969 | GEO | 2024/03/07

REPOSITORIES: GEO

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