Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq analysis of bulk Human and single-cell Musashi2-CreER-MycT58A; R26-LSL-tdTomato Mouse Pancreas ASCP, PDAC, and ACC Tumors

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE241233 | GEO | 2023/08/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

scRNA-seq analysis of Musashi2-CreER-MycT58A; R26-LSL-tdTomato Mouse pre-cancer derived Pancreas ASCP, PDAC, and ACC Tumors (post transplantation)

Project description:Identifying the cells from which cancers arise, and the paths they take towards malignancy is critical for understanding the molecular basis of tumor initiation and progression. To determine whether stem and progenitor cells can serve as cells of origin for cancer, we created a new Msi2-CreERT2 knock-in strain. When crossed to a conditional CAG-LSL-MycT58A model, Msi2-CreERT2 mice developed multiple pancreatic cancer subtypes: pancreatic ductal adenocarcinoma (PDAC), adenosquamous carcinoma of the pancreas (ASCP), acinar cell carcinoma (ACC), and rare anaplastic tumors. Combining single-cell genomics with computational analysis of developmental states and lineage trajectories, we demonstrate that oncogenic MYC preferentially triggers the transformation of the most immature subset of Msi2+ cells, leading to the rise of a common pool of pre-cancer cells with multi-lineage properties. These pre-cancer cells subsequently diverge to distinct pancreatic cancer subtypes by activation of distinct transcriptional programs and large-scale genomic changes. Importantly, the enforced expression of specific molecular signals can redirect cells toward specific subtypes. This study shows that multiple pancreatic cancer subtypes can arise from a common pool of Msi2+ cells and provides a powerful framework to understand and control the programs that shape divergent fates in pancreatic cancer.

2023-08-22 | GSE241231 | GEO

RNA-seq analysis of bulk Human and single-cell Musashi2-CreER-MycT58A R26-LSL-tdTomato Mouse Pancreas ASCP, PDAC, and ACC Tumors

Project description:RNA-seq analysis of bulk Human and single-cell Musashi2-CreER-MycT58A R26-LSL-tdTomato Mouse Pancreas ASCP, PDAC, and ACC Tumors

| PRJNA1006761 | ENA

scRNA-seq analysis of Musashi2-CreER-MycT58A R26-LSL-tdTomato Mouse pre-cancer derived Pancreas ASCP, PDAC, and ACC Tumors (post transplantation)

Project description:scRNA-seq analysis of Musashi2-CreER-MycT58A R26-LSL-tdTomato Mouse pre-cancer derived Pancreas ASCP, PDAC, and ACC Tumors (post transplantation)

| PRJNA1006763 | ENA

Bulk RNA-seq analysis of Human ASCP and ACC Pancreas Tumors

2023-08-21 | GSE241226 | GEO

scRNA-seq analysis of Msi2CreER-MycT58A Mouse Pre-cancer and Pancreas ASCP tumor

Project description:scRNA-seq analysis evaluating transcriptional heterogeneity in mouse pre-cancer and pancreas tumors in an effort to model the progression of pancreas tumors. Single cells were captured at t=0 (before tamoxifen induction), t=5 (5 weeks after tamoxifen induction) and t=12 (12 weeks after tamoxifen induction).

2023-03-01 | GSE182396 | GEO

scATAC-seq analysis of Msi2CreER-MycT58A Mouse Pre-cancer and Pancreas ASCP tumor

Project description:scATAC-seq analysis evaluating epigenetic heterogeneity in mouse pre-cancer and pancreas ASCP tumor

2023-03-01 | GSE181408 | GEO

Bulk RNA-seq analysis of Human ASCP and ACC Pancreas Tumors

Project description:Bulk RNA-seq analysis of Human ASCP and ACC Pancreas Tumors

| PRJNA1006756 | ENA

Bulk RNA-seq analysis of Msi2-MycT58A Mouse Pancreas Tumors

Project description:RNA-seq comparative analysis of Msi2-MycT58A Mouse Pancreas Tumors

2023-03-01 | GSE181166 | GEO

scRNA-seq analysis of Msi2CreER-MycT58A Mouse Pre-cancer and Pancreas ASCP tumor

Project description:scRNA-seq analysis of Msi2CreER-MycT58A Mouse Pre-cancer and Pancreas ASCP tumor