Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MRNA expression-based, potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

ABSTRACT: mRNA expression in liver of rats(3, high fat diet group, 3, high fat diet + HTG treatment, 3) were detected, and differentially expressed mRNAs were analyzed to reveal potential mechanism of HTG in treating dyslipidaemia.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE241805 | GEO | 2023/11/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

miRNA expression-based, potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

Project description:Potential mechanism was discovered through expression profiling of a total of 3545 miRNAs in liver of rats fed with high fat diet after HTG treatment. MiRNAs in liver of rats(3 group, normal fat diet group, 3, high fat diet group, 3, high fat diet + HTG treatment, 3) were detected, and differentially expressed miRNAs were analyzed to reveal potential mechanism of HTG in treating dyslipidaemia.

2023-11-21 | GSE241806 | GEO

Potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

Project description:Potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

| PRJNA1010123 | ENA

Potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-21 | GSE241807 | GEO

mRNA expression-based, potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

Project description:mRNA expression-based, potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

| PRJNA1010128 | ENA

miRNA expression-based, potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

Project description:miRNA expression-based, potential mechanism of a herbal medicine formula HTG in treating dyslipidaemia rats

| PRJNA1010127 | ENA

Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis.

Project description:BackgroundHuazhuo Tiaozhi granule (HTG) is a herbal medicine formula widely used in clinical practice for hypolipidaemic effects. However, the molecular mechanisms underlying dyslipidaemia treatment have not been well elucidated.ResultsA significant reduction in the levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) was observed in the serum of patients with dyslipidaemia after HTG treatment, without disruption in the levels of aspartate transaminase (AST), alanine transaminase (ALT), urea nitrogen (BUN), and creatinine (Cr). The dyslipidaemia rat model was induced by a high-fat diet and treated with Xuezhikang (0.14 g/kg/d) or HTG (9.33 g crude herb/kg/day) by gavage for 8 weeks. Body weight and liver index were markedly decreased in dyslipidaemic rats after treatment with Xuezhikang or HTG. HTG administration markedly ameliorated hyperlipidaemia by decreasing the levels of TC and LDL-C in serum and hepatic lipid accumulation. In vitro, lipid accumulation in LO2 and HepG2 cells was alleviated by serum treatment with HTG. High lactylation was observed in 198 proteins, including lactylation of histone H2B (K6), H4 (K80). Deep sequencing of microRNAs showed that miR-155-5p was significantly downregulated.ConclusionsThis study demonstrates that HTG is an effective and safe formula for treating dyslipidaemia, which promotes lactylation in hepatocytes, and the retardation of miR-155-5p biogenesis.

| S-EPMC10623728 | biostudies-literature

Transcription profiling of human tracheal gland (HTG) cell line MM39 and cystic fibrosis HTG cell line CF-KM4 incubated with or without Pseudomonas aeruginosa supernatant

Project description:The Human Tracheal Gland (HTG) cell line MM39 and the CF HTG cell line CF-KM4 were incubated with or without a P. aeruginosa supernatant for 3 hours.

2009-10-23 | E-MEXP-1332 | biostudies-arrayexpress

Therapeutic Mechanisms of Chinese Herbal Medicine Qushi Huayu Decoction (QHD) in the Treatment of NAFLD

Project description:To understand the therapeutic mechanisms of QHD, we examined the effects of QHD treatment on the liver transcriptomes of NAFLD rats and identified multiple therapeutic targets of QHD. We used microarrays to examine the effects of QHD and GC treatment on the liver transcriptomes of NAFLD rats induced by high fat diet and identified multiple therapeutic targets of QHD.

2016-10-01 | GSE87432 | GEO

An herbal medicine-based formula affected the epithelial cell line, BEAS-2B, genes expression.

Project description:Coronavirus Disease 2019 (COVID-19) remains a threat on the fatal ARDS with an incidence rate of 41.8%, or irreversible pulmonary fibrosis, without specific effective therapeutic drugs. The infection causes dysregulation of the immune system with a cytokine storm in lung tissue. To define the drug candidate of Virofree to COVID-19 induced-ARDS, we treated 66.67 ug/ml and 500 ug/ml in epithelial cell line, BEAS-2B, and compared the PBS control group to obtain Virofree expression profiles.

2022-05-27 | GSE203547 | GEO

transcription profiling by array of C57BL/6J mice fed a Western-style diet with or without 0.05% quercetin against mice on a control diet to study the effect of quercetin on obesity and hepatic gene expression

Project description:To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression, C56BL/6J mice were fed for 20 weeks on control or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin. Chronic dietary intake of quercetin reduced body weight gain and visceral and liver fat accumulation, and improved hyperglyceamia, hyperinsulinaemia, dyslipidaemia in mice fed a Western-style diet. Feeding a Western-style diet altered expression of genes related to inflammatory responses, lipid metabolism and oxidative phosphorylation in C57BL/6J mice after 20 weeks. The results from exhaustive gene expression analysis showed that quercetin minimally influenced hepatic gene expression in mice fed the Western diet. The gene screening results (GSEA) were consistent with the notion that it did improve mitochondrial function to some extent. Quantitative RT-PCR analysis indicated that quercetin did influence important regulators of fat accumulation and metabolic disorders. Our results suggest that quercetin reduces fat accumulation presumably through decreasing oxidative stress and increasing PPARα expression, and the following improvement of gene expression related to steatosis in the liver. C56BL/6J mice were fed for 20 weeks on AIN93G (con) or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin for 20 weeks.

2012-05-29 | E-GEOD-38141 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data