Transcriptomics

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Skeletal muscle gene expression analysis of Shank3Δ11(-/-) and wildtype mice at postnatal day 0–1


ABSTRACT: We analyzed transcriptional differences by RNA-sequencing of muscle tissue of neonatal Shank3Δ11(-/-) mice and compared those to Shank3(+/+) controls. We found significant differences in gene expression of ion channels crucial for muscle contraction and for molecules involved in calcium ion regulation. In addition, calcium storage- (i.e. Calsequestrin (CSQ)), calcium secretion- and calcium- related signaling- proteins were found to be affected.

ORGANISM(S): Mus musculus

PROVIDER: GSE241812 | GEO | 2023/08/30

REPOSITORIES: GEO

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