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Enhancer-activated RET confers protection against oxidative stress to KMT2A-rearranged acute myeloid leukemia.

ABSTRACT: KMT2A-MLLT3, a fusion protein formed by the t(9;11) translocation in acute myeloid leukemia, is an epigenetic transcription factor that is known to regulate a unique leukemic gene expression profile. We show that rearranged during transfection (RET) proto-oncogene is highly overexpressed in the KMT2A-MLLT3 subgroup. In addition to biochemical studies, the RNA-seq and ATAC seq analyses have been performed in KMT2A-MLLT3 positive MOLM-13 AML cell line, compared to the umbilical cord blood-driven CD34+ hematopoietic stem progenitor cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE241867 | GEO | 2024/03/04

REPOSITORIES: GEO

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