Transcriptomics

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The Role of Nogo in asthma pathogenesis


ABSTRACT: In order to determine if there are any genetic differences among lungs of Nogo-A/B knockout mice which may explain their enhanced asthmatic-like responses, we have employed whole genome microarray expression profiling as a discovery platform to identify any genes that may be altered in the lung of Nogo-A/B knockout mice. RNA was isolated from three biological replicates of mouse lungs from naive WT and Nogo-A/B Knockout mice and run on agilent array. Two genes was significantly altered in Nogo-A/B Knockout lungs, SPLUNC1 and RTN4 (Nogo) which was significantly decreased and confirmed by real-time PCR.

ORGANISM(S): Mus musculus

PROVIDER: GSE24218 | GEO | 2010/10/20

SECONDARY ACCESSION(S): PRJNA133025

REPOSITORIES: GEO

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