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Tumorigenic effects of human mesenchymal stromal cells and fibroblasts on bladder cancer cells

ABSTRACT: We sought for deeper understanding of interaction mechanisms between tumor microenvironment cells, like fibroblast (FB) and mesenchymal stem cells (MSC), and bladder cancer cells to develop new cancer treatment approaches overcoming therapy resistance. To this end the bladder cancer cell lines BFTC-905 and VMCUB-1 were treated with conditioned media from FB or MSC for 72h. RNA was submitted to RNA sequencing analysis on the HiSeq 3000/4000 system (Illumina).

ORGANISM(S): Homo sapiens

PROVIDER: GSE242217 | GEO | 2023/09/04

REPOSITORIES: GEO

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Epigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissue and its overexpression in the urothelial carcinoma microenvironment

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