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Virus-specific TRM cells of both donor and recipient origin reside in human kidney transplants

ABSTRACT: Tissue-resident lymphocytes (TRLs) are critical for local protection against viral pathogens in peripheral tissue. However, it is unclear if TRLs perform a similar role in transplanted organs under chronic immunosuppressed conditions. The present study aimed to characterize the TRL compartment in human kidney transplant nephrectomies and examine its potential role in antiviral immunity. Paired single-cell transcriptome and T-cell receptor (TCR) sequencing showed that donor and recipient tissue-resident memory T (TRM) cells exhibit striking similarities in their transcriptomic profiles and share numerous TCR clonotypes predicted to target viral pathogens.

ORGANISM(S): Homo sapiens

PROVIDER: GSE242909 | GEO | 2023/09/11

REPOSITORIES: GEO

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