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Effect of GDNF-Gel/HA-Mg nerve conduit on gene expression during peripheral nerve regeneration

ABSTRACT: In this study, glial cell line-derived neurotrophic factor (GDNF)- Gelatin methacryloyl (Gel)/hydroxylapatite (HA)-Mg nerve conduit was developed. the conduit was implanted in sciatic nerve defect model in SD rats to explore its role in repairing peripheral nerve defects. Regenerated nerve tissues from GDNF-Gel/HA-Mg group and negative control group were collected for RNA-seq, aiming to explore the potential molecular mechanism of GDNF-Gel/HA-Mg in peripheral nerve regeneration.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE243282 | GEO | 2023/12/20

REPOSITORIES: GEO

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