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Serum exosomal miRNA profile in pregnancies with gestational diabetes based on pancreatic β-cell function

ABSTRACT: Pancreatic β-cell function impairment is a key mechanism for developing gestational diabetes mellitus (GDM). Maternal and placental exosomes regulate maternal and placental responses during hyperglycemia. Studies have associated exosomal micro RNAs (miRNAs) with GDM development. To date, no studies have been reported that evaluate the profile of miRNAs present in maternal and placental exosomes in the early stages of gestation from pregnancies that develop GDM. We used microarrays to assess whether early pregnancy maternal and placental exosomal miRNA profiles vary according to pancreatic β-cell function in women who will develop GDM (preGDM).

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE243374 | GEO | 2024/02/29

REPOSITORIES: GEO

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