Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profiles at the single nuclei level of hypothalamic oxytocin neurons from mice fed either standard chow (SC) diet or high-fat/high-sugar (HFHS) diet

ABSTRACT: To explore the transcriptional heteroeneity of oxytocin neurons, we fluorescence-assisted nuclei sorting (FANS) conditionally tagged nuclei from Oxt-ires-Cre;CAG-Sun1sfGFP mice. All mice were littermates and fed either SC diet or HFHS diet for 4 months. Individual nuclei were sorted into 384w plates and subjected to SMART-seq2.

ORGANISM(S): Mus musculus

PROVIDER: GSE243448 | GEO | 2023/09/21

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcriptomic profile of replicating NAFLD hepatocytes (from High-Fat High-Sucrose Diet - HFHS and Choline-Deficient High-Fat Diet - CDHFD).

Project description:C57Bl6/J male mice were put on different diets at 5 weeks of age, with a standard diet (SD) or a High-Fat High-Sucrose Diet (HFHS) or a Choline-Deficient High-Fat Diet (CDHFD) during 6 months. Primary hepatocytes cultures from 3 different models were synchronized in the cell cycle. Transcriptomic analysis was perfomed at 48hours of culture when HFHS and CDHFD hepatocytes harbor replication stress.

2020-07-11 | GSE154194 | GEO

Gene expression profile at single cell level of cells derived from the arcuate nucleus of the hypothalamus (ARC) of mice fed with standard chow (SC) or high-fat high-sugar (HFHS) diet

Project description:Hypercaloric diet affects hypothalamic cells at different levels. However, the time-dependent transcriptional changes of hypothalamic cells, and more particularly ARC cells, following the exposure to a HFHS diet are largely unknown. We used single cell RNA sequencing (scRNA-Seq) to analyze the impact of HFHS diet feeding on the transcriptional profile of ARC cells at different timepoints, with a special focus on astrocytes. The timepoints analyzed consist in 5 and 15 days of HFHS diet exposure, at which mice gain a not significant or a significant body weight respectively.

2022-06-10 | GSE205667 | GEO

Gene expression profiles at the single nuclei level of hypothalamic oxytocin neurons from mice fed either standard chow (SC) diet or high-fat/high-sugar (HFHS) diet

Project description:Gene expression profiles at the single nuclei level of hypothalamic oxytocin neurons from mice fed either standard chow (SC) diet or high-fat/high-sugar (HFHS) diet

| PRJNA1018514 | ENA

Epigenome analysis of liver tissues from Pemt-/- and Pemt+/+ under high fat-high sucrose (HFHS) diet

Project description:Genome wide DNA methylation profiling of liver tissues from Pemt-/- and Pemt+/+ under HFHS diets. Pemt-/- and Pemt+/+ mice were fed HFHS from 5 to 25 weeks of age and liver tissues were obtained at 25 weeks. Bisulphite converted DNAs were enriched with EpiXplore Methylation DNA Enrichment Kit (Clontech). Genomic DNA libraries was prepared by TruSeq ChIP Sample Preparation Kit.

2015-04-14 | E-GEOD-67791 | biostudies-arrayexpress

Expression data from liver samples of Pemt-/- and Pemt+/+ mice under high fat-high-sucrose (HFHS) diet

Project description:We used microarrays to detail the global programme of gene expression in the liver of Pemt-/- and Pemt+/+ under HFHS diets. Liver sample of Pemt-/- and Pemt+/+ mice under HFHS for 1, 2, 3, 4 weeks were used for RNA extraction and hybridization on Affymetrix microarrays. Genes in liver of Pemt-/- mice, successively suppressed compared with Pemt+/+ mice, were obtained.

2015-04-14 | E-GEOD-67792 | biostudies-arrayexpress

Comparision of hepatic gene expression between HFHS diet-fed WT and CREBH-Tg mice

Project description:To determine CREBH-mediated hepatic gene expression changes in hifh-fat high-sucrose (HFHS) dit feeding, we employed the microarray analysis. We collected the livers from male WT and CREBH-Tg mice fed with HFHS diet for 12 weeks from 6 weeks old.

2020-01-11 | GSE143421 | GEO

Transcriptomic profiling across 20 CC-RIX genetic backgrounds with and without high-fat high-sugar (HFHS) diet, and with and without metformin [adipose]

Project description:Adipose, liver, and skeletal muscle tissue from 6-month and 12-month CC-RIX cohorts underwent transcriptomic profiling. CC-RIX cohorts were exposed to sensitizer (HFHS diet) and a widely used pharmaceutical intervention (metformin). Chow (control) or high fat high sugar (HFHS) diet started at 6 weeks of age.. At six months of age, a subset of mice from each chow group and of each sex were euthanized for tissue collection. At 7 months of age, half of the remaining mice in each diet treatment group will receive metformin treatment. In a subset of the 12 month cohort animals, metformin (5 mg/mL) was delivered ad libitum in the drinking water (Chang, Moro et al. 2018). Terminal phenotyping and tissue collection was done at 12 months of age.

2024-11-05 | GSE237737 | GEO

Transcriptomic profiling across 20 CC-RIX genetic backgrounds with and without high-fat high-sugar (HFHS) diet, and with and without metformin [liver]

2024-11-05 | GSE237743 | GEO

Transcriptomic profiling across 20 CC-RIX genetic backgrounds with and without high-fat high-sugar (HFHS) diet, and with and without metformin [skeletal muscle]

2024-11-05 | GSE237747 | GEO