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SORBS2 regulates integrin-cytoskeleton interactions and extracellular matrix composition in heart failure

ABSTRACT: Heart failure is associated with high mortality rates and reduced quality of life. Because of the tight connection between Nppa expression and cardiomyocyte stress, we first determined NPPA correlated genes during heart failure. In this study, we identify SORBS2 as conserved NPPA correlated gene and detail its molecular function and association with heart failure. We used RNA-sequencing on murine whole heart tissue to study the effect of cardiomyocyte-specific genetic loss of Sorbs2 in adult mice in a healthy situation and heart failure model.

ORGANISM(S): Mus musculus

PROVIDER: GSE243463 | GEO | 2025/03/17

REPOSITORIES: GEO

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SORBS2 regulates integrin-cytoskeleton interactions and extracellular matrix composition in heart failure

Project description:SORBS2 regulates integrin-cytoskeleton interactions and extracellular matrix composition in heart failure

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