Other

Dataset Information

0

Rare variation in noncoding regions with evolutionary signatures contributes to autism spectrum disorder risk


ABSTRACT: We examined three classes of noncoding regions with different patterns of conservation and constraint: Human Accelerated Regions (HARs), which show signatures of positive selection in the human lineage; experimentally validated neural Vista Enhancers (VEs); and candidate neural enhancers (CNEs). We interrogate the in vitro enhancer activity of HARs, VEs, and CNEs in capture-based massively parallel reporter assays (caMPRAs). We also perform random mutagenesis on HARs to assess the effeects of single nucleotide variants on enhancer activity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE243549 | GEO | 2024/05/13

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-07-24 | GSE180714 | GEO
2018-02-17 | GSE110759 | GEO
2018-02-17 | GSE110758 | GEO
2022-12-21 | GSE183137 | GEO
2010-08-22 | E-GEOD-22549 | biostudies-arrayexpress
2024-06-25 | GSE270272 | GEO
2024-07-05 | GSE270828 | GEO
2019-11-26 | GSE140983 | GEO
2024-08-15 | PXD054928 | Pride
2016-12-12 | PXD005253 | Pride