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BRD4 inhibitor GNE987 exerts anti-cancer effects in Osteosarcoma

ABSTRACT: GNE987 is a newly developed von Hippel-Lindau tumor suppressor (VHL)-based pan-BET-targeting PROTAC, which can bind to the target proteins (BET proteins, including BRD2, BRD3, and BRD4) and recruit them to the ubiquitin/proteasome system for selective degradation. In the our study, ChIP-Seq analysis was performed to explore the effect of GNE987 on osteosarcoma cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE243673 | GEO | 2024/08/08

REPOSITORIES: GEO

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