Genomics

Dataset Information

0

Single cell ATAC-sequencing analysis of human SUV39H1-knockout CAR T compared to control CAR T cells (mock) in a xenograft model of lung adenocarcinoma


ABSTRACT: We have observed that the inactivation of SUV39H1 enhances 41BBz-CAR T cell long-term persistence, providing protection against tumor relapses and rechallenges in a xenograft mouse model of lung adenocarcinoma. The purpuse of this study was to profile chromatin accessibility of SUV39H1-deficient compared to mock 41BBz-CAR T cells by single-cell assay for transposase accessible chromatin (scATAC-seq) on FACS-sorted T cells eight days after CAR T cell infusion into the mice.

ORGANISM(S): Homo sapiens

PROVIDER: GSE244029 | GEO | 2023/10/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-10-31 | GSE244028 | GEO
2023-11-03 | GSE246960 | GEO
2023-10-31 | GSE244030 | GEO
2023-10-27 | GSE245184 | GEO
2023-10-27 | GSE245186 | GEO
| PRJNA1021138 | ENA
| PRJNA1021140 | ENA
| PRJNA1021137 | ENA
| PRJNA1027320 | ENA
| PRJNA1021067 | ENA