Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of MC903-OVA model with basophils VAMP7 knockout mouse

ABSTRACT: Differential gene expression of basophil VAMP7 knockout in MC903-OVA induced acute pruritus model

ORGANISM(S): Mus musculus

PROVIDER: GSE244238 | GEO | 2023/11/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

RNA-seq of MC903 model with basophils VAMP7 knockout mouse

Project description:Differential gene expression of basophil VAMP7 knockout in MC903 induced acute pruritus model

2023-11-08 | GSE245289 | GEO

MC903 / Calcipotriol mouse model treated with GLPG2534 or dexamethasone

Project description:The goal of the experiment is to assess the effect of GLPG2534 and dexamethasone in the MC903 mouse model for atopic dermatitis in a therapeutic setting.

2023-01-15 | E-MTAB-10015 | biostudies-arrayexpress

RNA-seq of MC903 model with SB328437 treatment

Project description:Differential gene expression of SB328437 treatment in MC903 model

2023-11-08 | GSE246992 | GEO

Cebpa regulates gene transcription in basophils

Project description:To investigate the mechanisms by which C/EBPa drives basophil differentiation and maintains basophil identity, we examined whether or not C/EBPa promotes basophil molecular programming and simultaneously represses mast cell molecular programming. We performed genome-wide gene expression profiling on basophils and mast cells and found that 6798 genes were shared by mast cells and basophils; 2033 genes were expressed 2-10 (log2 1-3.3)-fold higher in basophils (differentially expressed in basophils); and 413 genes were expressed greater than 10 (log2 3.3)-fold in basophils (highly expressed in basophils). On the other hand, we found 569 genes were expressed 2-10 (log2 -1 to -3.3) fold higher in mast cells and 171 genes were highly expressed in mast cells [greater than 10 fold (log2 -3.3)]. We treated purified basophils prepared from Cebpaf/f RosaYFP/creER mice and Cebpa+/+ RosaYFP/creER control mice with or without 4HT treatment for five days. Gene expression in the treated basophils was analyzed using microarray analysis. Overall, deletion of C/EBPa in basophils resulted in a reduction of mRNA expression for 248 genes and led to an increase in mRNA expression for 255 genes. The majority of the C/EBPa-regulated genes were either differentially or highly expressed in basophils or mast cells. In this study, we compared gene expression in basophils and mast cell and identified genes which specifically expressed in basophils and mast cells. By using Cebpa conditional knock out mice, we identified Cebpa regulated genes in basophils.

2013-04-01 | E-GEOD-41596 | biostudies-arrayexpress

Urotensin II/GPR14 Pathway Regulates Chronic Itch in Mice

Project description:In order to analyze the regulatory effects of UII and GPR14 on gene transcription in Mc903-induced atopic dermatitis skin, ear skin collected from MC903 chronic itch mouse model on day 13 was used for in-depth analysis and sequencing of skin gene expression. The effect of GSK1562590 on the expression of pruritus and inflammatory factors in dermatitis was detected by RNA-seq.

2023-06-16 | GSE226669 | GEO

Effects of OVA challenge in mouse model of asthma

Project description:Challenge with ovalbumin antigen is a common model for asthma in mice. We sought to identify the gene expression differences in lung tissue in naïve and OVA-sensitized mice, in response to OVA challenge.

2015-10-11 | GSE41665 | GEO

Effect of RGRN-305 on MC903-induced skin inflammation in mice

Project description:The aim was to demonstrate that RGRN-305 suppresses MC903-induced atopic dermatitis like-alterations in gene expression.

2023-12-31 | GSE246569 | GEO

RNA-seq of tissues from MC903- and Ethanol-treated mice

Project description:We report transcript abundance in skin, spinal_cord, and trigeminal ganglia from animals treated with MC903 to induce a mouse model of atopic dermatitis across different genotypes, time points, and treatments

2019-11-13 | GSE132173 | GEO

RNA-sequencing of mouse Lang+ and Lang- migratory dendritic cells (DC) under 2 pathogenic conditions of atopic dermatitis

Project description:Comparison of mouse Lang+ and Lang- migratory dendritic cells (DC) under 2 pathogenic conditions of atopic dermatitis (MC903-treated and OVA treated)

2023-04-20 | GSE149039 | GEO

Effects of interleukin-4 receptor blockade in experimental conjunctivitis evoked by skin inflammation

Project description:To characterize conjunctivitis and the effects of IL-4Ra signaling at the transcriptomic level, we performed RNA sequencing (RNA-Seq) on conjunctival tissues in OVA-challenged mice that received isotype or anti-IL-4Ra treatment, as well as control mice that were ocularly challenged with PBS (MC903+OVA/PBS)

2022-11-16 | GSE217899 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data