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Parallel neural pathways control sodium consumption and taste valence

ABSTRACT: We performed single-cell RNA-seq (10x Chromium 3' v.3.1) on dissociated single cell suspensions from mouse (C57BL/6) osmosensory brain nuclei - subfornical organ (SFO) to determine transcriptomic cell types and neuronal activation patterns. By performing single cell RNA-seq based stimulus to cell-type mapping, we captured the endogenous immediate early gene expression triggered by distinct physiological state stimuli in SFO cells. We identified a unique excitatory neuron type in SFO that is uniquely tuned to sodium deficiency.

ORGANISM(S): Mus musculus

PROVIDER: GSE244245 | GEO | 2023/12/22

REPOSITORIES: GEO

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