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Genome-wide identification of target genes for the transcription factors Nkx2.2 and Zfp488 in differentiating CG4 cells as a model for differentiating oligodendrocytes

ABSTRACT: In an attempt to validate the CG4 cell line as a model for oligodendrocytes, we determined the expression profiles in both cell types and the alterations during differentiation and found a striking overlap. Using CG4 cells as a model system for oligodendroglial cells, we generated several Nkx2.2 and Zfp488 overexpressing CG4 lines and compared their expression profile under differentiating conditions to regular CG4 cells to identify target genes of the two transcription factors in a genome-wide and unbiased approach. Several target genes were shared between Nkx2.2 and Zfp488, among them Gpr37.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE244592 | GEO | 2024/03/27

REPOSITORIES: GEO

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