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An integrated toolkit for human microglia functional genomics

ABSTRACT: Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these processes. However, existing iMG generation protocols face challenges, such as prolonged differentiation time, lack of detailed characterization, and limited gene function investigation via CRISPR-Cas9. In this study will generated iMG from human iPSCs using our newly developed protocol. We used single cell RNA-Seq to study the transcriptomic profiles of our newly formed iMG. The single cell RNA-Seq data under this accession is from wild type iMG (Hashtag 7) and OTHER KO iMG (Hashtag 8)

ORGANISM(S): Homo sapiens

PROVIDER: GSE244653 | GEO | 2024/04/17

REPOSITORIES: GEO

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