HA-1-targeted T cell receptor (TCR) T cell therapy for recurrent leukemia after hematopoietic stem cell transplantation: results from a phase I clinical trial.
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ABSTRACT: Tumors escape antigen-directed immunotherapies through a variety of mechanisms. We used single-cell RNA sequencing (scRNA-seq) to examine potential mechanisms of immune escape in patients with disease relapse or progression after T cell receptor T cell (TCR-T) immunotherapy directed against the minor histocompatibility antigen HA-1.
ORGANISM(S): Homo sapiens
PROVIDER: GSE244663 | GEO | 2024/01/01
REPOSITORIES: GEO
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