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Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance

ABSTRACT: Microglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. We aimed at understanding the role of Rac1 on microglia functions. Here, we used conditional cell-specific gene targeting in mice with multi-omics approaches, and demonstrated that the RhoGTPase Rac1 was an essential requirement for the microglia to sense and interpret the brain microenvironment, and for crucial microglia-synapse crosstalk driving experience-dependent plasticity, a fundamental brain property impaired in several neuropsychiatric disorders.

ORGANISM(S): Mus musculus

PROVIDER: GSE244773 | GEO | 2023/10/23

REPOSITORIES: GEO

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Microglial Rac1 is essential for experience-dependent brain plasticity and cognitive performance

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