Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE244795 | GEO | 2024/07/31

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [Nanostring panel]

Project description:HBS/AS01 adjuvanted vaccine induces changes in the chromatin structure of monocytes after vaccination, an effect that lasts until 6 months post vaccination

2024-07-31 | GSE244799 | GEO

AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [RNA-seq]

Project description:HBS/AS01 adjuvanted vaccine induces changes in the chromatin structure in monocytes impacting their gene expression profiles, an effect that lasts until 6 months post vaccination

2024-07-31 | GSE244794 | GEO

AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [scRNA-seq]

2024-07-31 | GSE244793 | GEO

AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [scATAC-seq]

Project description:HBS/AS01 adjuvanted vaccine induces changes in the chromatin structure in monocyte population impacting their gene expression, an effect that lasts until 6 months post vaccination

2024-07-31 | GSE244792 | GEO

Transcriptional signatures to AS01-adjuvanted tuberculosis vaccine in naïve and primed participants

Project description:In this exploratory post-hoc analysis of clinical trial samples (clinicalTrials.gov: NCT01424501), we compared gene expression patterns elicited by two immunizations with the candidate tuberculosis (TB) vaccine M72/AS01, between three groups of individuals with different levels of memory responses to TB antigens before vaccination

2022-11-16 | GSE197408 | GEO

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFN? response promoting vaccine immunogenicity.

Project description:Combining immunostimulants in adjuvants can improve the quality of the immune response to vaccines. Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3-O-desacyl-4'-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System AS01. AS01 is part of the malaria and herpes zoster vaccine candidates that have demonstrated efficacy in phase III studies. Hours after injection of AS01-adjuvanted vaccine, resident cells, such as NK cells and CD8+ T cells, release IFN? in the lymph node draining the injection site. This effect results from MPL and QS-21 synergy and is controlled by macrophages, IL-12 and IL-18. Depletion strategies showed that this early IFN? production was essential for the activation of dendritic cells and the development of Th1 immunity by AS01-adjuvanted vaccine. A similar activation was observed in the lymph node of AS01-injected macaques as well as in the blood of individuals receiving the malaria RTS,S vaccine. This mechanism, previously described for infections, illustrates how adjuvants trigger naturally occurring pathways to improve the efficacy of vaccines.

| S-EPMC5627273 | biostudies-literature

Distinct functional programming of human fetal and adult monocytes

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-05-02 | E-GEOD-54818 | biostudies-arrayexpress

A randomized trial assessing the safety and immunogenicity of AS01 and AS02 adjuvanted RTS,S malaria vaccine candidates in children in Gabon.

Project description:The malaria vaccine candidate antigen RTS,S includes parts of the pre-erythrocytic stage circumsporozoite protein fused to the Hepatitis B surface antigen. Two Adjuvant Systems are in development for this vaccine, an oil-in water emulsion--based formulation (AS02) and a formulation based on liposomes (AS01).In this Phase II, double-blind study (NCT00307021), 180 healthy Gabonese children aged 18 months to 4 years were randomized to receive either RTS,S/AS01(E) or RTS,S/AS02(D), on a 0-1-2 month vaccination schedule. The children were followed-up daily for six days after each vaccination and monthly for 14 months. Blood samples were collected at 4 time-points. Both vaccines were well tolerated. Safety parameters were distributed similarly between the two groups. Both vaccines elicited a strong specific immune response after Doses 2 and 3 with a ratio of anti-CS GMT titers (AS02(D)/AS01(E)) of 0.88 (95% CI: 0.68-1.15) post-Dose 3. After Doses 2 and 3 of experimental vaccines, anti-CS and anti-HBs antibody GMTs were higher in children who had been previously vaccinated with at least one dose of hepatitis B vaccine compared to those not previously vaccinated.RTS,S/AS01(E) proved similarly as well tolerated and immunogenic as RTS,S/AS02(D), completing an essential step in the age de-escalation process within the RTS,S clinical development plan.ClinicalTrials.gov. NCT00307021.

| S-EPMC2763199 | biostudies-literature

Ovine HSP90AA1 gene promoter: functional study and epigenetic modifications.

Project description:When environmental temperatures exceed a certain threshold, the upregulation of the ovine HSP90AA1 gene is produced to cope with cellular injuries caused by heat stress. It has been previously pointed out that several polymorphisms located at the promoter region of this gene seem to be the main responsible for the differences in the heat stress response observed among alternative genotypes in terms of gene expression rate. The present study, focused on the functional study of those candidate polymorphisms by electrophoretic mobility shift assay (EMSA) and in vitro luciferase expression assays, has revealed that the observed differences in the transcriptional activity of the HSP90AA1 gene as response to heat stress are caused by the presence of a cytosine insertion (rs397514115) and a C to G transversion (rs397514116) at the promoter region. Next, we discovered the presence of epigenetic marks at the promoter and along the gene body founding an allele-specific methylation of the rs397514116 mutation in DNA extracted from blood samples. This regulatory mechanism interacts synergistically to modulate gene expression depending on environmental circumstances. Taking into account the results obtained, it is suggested that the transcription of the HSP90AA1 ovine gene is regulated by a cooperative action of transcription factors (TFs) whose binding sites are polymorphic and where the influence of epigenetic events should be also taken into account.

| S-EPMC4595440 | biostudies-literature

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-09-30 | E-GEOD-61722 | biostudies-arrayexpress