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ScRNA-seq mouse splenocytes prior to and during blood-stage malaria infection.

ABSTRACT: Blood-stage malaria infection induces differentiation of several effector CD4 + T subsets including Tfh and Th1 cells. The cues and microarchitectural niches required in secondary lymphoid organs for their formation were previously uncharacterised. Here we used scRNA-seq to profile splenocyte transcriptomes at steady state or upon malaria infection as a reference dataset for deconvolution of spatial transcriptomic data.

ORGANISM(S): Mus musculus

PROVIDER: GSE244804 | GEO | 2024/07/08

REPOSITORIES: GEO

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