Transcriptomics

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Gene expression data from C57BL/6J mice exposed to 3 days of hypoxia


ABSTRACT: Pulmonary hypertension (PH) is a chronic vascular disease characterised, amongst other abnormalities, by hyperproliferative smooth muscle cells and a perturbed cellular redox and metabolic balance. Oxidants induce cell cycle arrest to halt proliferation; however, little is known about the redox-regulated effector proteins that mediate these processes. Here, we report a novel kinase-inhibitory disulfide bond in cyclin D-CDK4 and investigate its role in cell proliferation and PH. We used an Affymetrix microarray to look at the gene expression profile of mouse lungs exposed to normobaric hypoxia (10% oxygen) or normoxia and identified genes that were differentially expressed in response to hypoxia.

ORGANISM(S): Mus musculus

PROVIDER: GSE244830 | GEO | 2023/10/31

REPOSITORIES: GEO

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