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Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency [NovaA-186]

ABSTRACT: A single cell transcriptional profile of growth plate cells of the murine femur at postnatal day 36 (P36), lineage-marked by PTHrP-creER at P6

ORGANISM(S): Mus musculus

PROVIDER: GSE244880 | GEO | 2023/10/11

REPOSITORIES: GEO

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Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency [NovaA-237]

Project description:A single cell transcriptional profile of growth plate cells of the murine femur at postnatal day 36 (P36), lineage-marked by PTHrP-creER at P6, Control

2023-10-11 | GSE244881 | GEO

Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency.

Project description:The resting zone of the postnatal growth plate is organized by slow-cycling chondrocytes expressing parathyroid hormone-related protein (PTHrP), which include a subgroup of skeletal stem cells that contribute to the formation of columnar chondrocytes. The PTHrP-Indian hedgehog feedback regulation is essential for sustaining growth plate activities; however, molecular mechanisms regulating cell fates of PTHrP+ resting chondrocytes and their eventual transformation into osteoblasts remain largely undefined. Here, in a mouse model, we specifically activated Hedgehog signaling in PTHrP+ resting chondrocytes and traced the fate of their descendants using a tamoxifen-inducible Pthrp-creER line with patched-1-floxed and tdTomato reporter alleles. Hedgehog-activated PTHrP+ chondrocytes formed large, concentric, clonally expanded cell populations within the resting zone ("patched roses") and generated significantly wider columns of chondrocytes, resulting in hyperplasia of the growth plate. Interestingly, Hedgehog-activated PTHrP+ cell descendants migrated away from the growth plate and transformed into trabecular osteoblasts in the diaphyseal marrow space in the long term. Therefore, Hedgehog activation drives resting zone chondrocytes into transit-amplifying states as proliferating chondrocytes and eventually converts these cells into osteoblasts, unraveling a potentially novel Hedgehog-mediated mechanism that facilitates osteogenic cell fates of PTHrP+ skeletal stem cells.

| S-EPMC10906233 | biostudies-literature

Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-11 | GSE244884 | GEO

Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency [NovaA-186]

Project description:Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency [NovaA-186]

| PRJNA1025268 | ENA

Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency

Project description:Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency

| PRJNA1025271 | ENA

Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency [NovaA-237]

Project description:Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency [NovaA-237]

| PRJNA1025269 | ENA

Single-cell RNAseq analysis of mesenchymal cells in the periodontal space of the murine molar

Project description:A single cell transcriptional profile of mesenchymal cells in the periodontal space of the murine molar marked by 2.3kb Col1a1-GFP or PTHrP-creER-lineage marked cells at postnatal day 25 (P25)

2021-03-09 | GSE168450 | GEO

Single-cell RNAseq analysis of Gli1-GFP+ tooth roor progenitor cells and PTHrP+ dental follicle cells of the murine molar

Project description:A single cell transcriptional profile of both epithelial and mesenchymal cells in the tooth bud of the murine molar marked by Gli1-GFP+ tooth root progenitor cells or PTHrP+ dental follicle cells at postnatal day 6 (P6)

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Single-cell RNAseq analysis of Gas1-creER-marked bone marrow stromal cells in young bones [Gas1CE;R26RtdT]

Project description:A single cell transcriptomic profile of Gas1-creER-marked bone marrow stromal cells of the murine femur at postnatal day 23 (P23), pulsed at P21.

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Single-cell RNAseq analysis of Fgfr3-creER-marked bone marrow stromal cells in young bones [Fgfr3CE;R26RtdT]

Project description:A single cell transcriptomic profile of Fgfr3-creER-marked bone marrow stromal cells of the murine femur at postnatal day 23 (P23), pulsed at P21.

2021-10-16 | GSE185792 | GEO

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