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Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE245025 | GEO | 2023/10/14

REPOSITORIES: GEO

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Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression (piRNA)

Project description:Pachytene piRNAs control male fertility across metazoans, yet mechanisms through which they govern meiosis I in pachytene remain unclear. We demonstrate, in C. elegans, that homolog pairing, and crossover formation are compromised in the absence of piRNA function. We identify several protein coding genes as targets of piRNAs including Polo like kinase 3 (PLK-). Pachytene piRNAs spatially restrict and exclude PLK-3 expression from meiosis I. Expansion of PLK-3 expression into the pachytene region, upon loss of piRNAs, is reflected in meiotic defects, which are partially rescued by removal of ectopic PLK-3. Pachytene piRNAs regulate PLK-3 through both translational repression and post-transcriptional degradation establishing the spatiotemporal control of gene expression. Given the conserved role of pachytene piRNAs, we propose that these mechanisms may be applicable to mammals.

2023-10-14 | GSE245023 | GEO

Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression (siRNA)

2023-10-14 | GSE245020 | GEO

Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression [piRNA_hermaphrodite]

2024-07-12 | GSE271909 | GEO

Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression [piRNA_RNAIP]

2024-07-12 | GSE271910 | GEO

Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression

Project description:Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression

| PRJNA1026633 | ENA

Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression (siRNA)

Project description:Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression (siRNA)

| PRJNA1026641 | ENA

Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression (piRNA)

Project description:Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression (piRNA)

| PRJNA1026642 | ENA

Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression [piRNA_hermaphrodite]

Project description:Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression [piRNA_hermaphrodite]

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Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression [piRNA_RNAIP]

Project description:Pachytene piRNAs govern male meiosis I by spatial restriction of gene expression [piRNA_RNAIP]

| PRJNA1134096 | ENA

A Global Expression Switch Marks Pachytene Initiation during Mouse Male Meiosis.

Project description:Male spermatogenesis is an essential and complex process necessary to gain totipotency and allow a whole new organism to develop upon fertilization. While single-gene based studies have provided insights into the mechanisms underlying spermatogenesis, detailed global profiling of all the key meiotic stages is required to fully define these processes. Here, by isolating highly enriched mouse meiotic cell populations, we have generated a comprehensive gene expression atlas of mammalian meiosis. Our data define unique signatures for the specific stages of meiosis, including global chromosome X inactivation and reactivation. The data also reveal profound switches in global gene expression at the initiation of pachynema that are reminiscent of the commitment to meiosis observed in budding yeast. Overall, this meiotic atlas provides an exhaustive blueprint and resource for mammalian gametogenesis and meiosis.

| S-EPMC3966219 | biostudies-literature

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