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Oncofetal reprogramming of the tumor vasculature

ABSTRACT: Certain embryonic genes, such as carcinoembryonic antigens (CEA) and oncofetal antigens, become re-expressed in malignant transformation and we hypothesized that a similar phenomenon features tumor endothelial cells as well. Therefore, we performed a systematic search for mouse embryo-specific gene expression at days E11 and E18 in comparison to adult mouse and queried for overexpression of these genes in sorted murine tumor endothelial cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE245218 | GEO | 2025/04/09

REPOSITORIES: GEO

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