Transcriptomics

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Gene expression profiles of newly generated MLL-AF9 leukemia cells and aggressive MLL-AF9 leukemia cells generated through serial transplantations.


ABSTRACT: Immunogenicity of acute myeloid leukemia (AML) keeps changing during tumor evolution, showing a trend that the aggressive AMLs generate through serial transplantations are susceptible to NK cell-mediated tumor suppression. To access molecular differences between the newly developed AML cells and aggressive AML cells generated through serial transplantations, we performed RNA-seq using newly generated mouse AML cells trasduced with MLL-AF9, and the aggressive MLL-AF9 cells obtained after 5 times serial transplantations in the non-irradiated recipient mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE245358 | GEO | 2023/12/27

REPOSITORIES: GEO

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