Transcriptomics

Dataset Information

0

Gene expression during CCK-induced damaged pancreatic acinar cells with or without the addition of OCA


ABSTRACT: Obeticholic acid (OCA) has shown pharmacological protection activity in acinar cell injury and pancreatic necrosis in vitro. RNA sequencing was performed by extracting mRNA from CCK-induced damaged pancreatic acinar cells with or without the addition of OCA. Gene enrichment analysis by Kyoto Encyclopedia of Genes and Genomes (KEGG) identified oxidative phosphorylation in the top ten significantly changed pathways. Similarly, Gene Set Enrichment Analysis (GSEA) enrichment analysis revealed clear alterations in "mitochondrial ATP synthesis coupled electron transport", "mitochondrial respiratory chain complex assembly", "NADH dehydrogenase complex assembly", and "oxidative phosphorylation".

ORGANISM(S): Mus musculus

PROVIDER: GSE245795 | GEO | 2023/12/31

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2016-01-27 | E-GEOD-73624 | biostudies-arrayexpress
2024-04-11 | GSE263273 | GEO
2014-07-21 | E-GEOD-49113 | biostudies-arrayexpress
2024-04-09 | GSE243726 | GEO
2024-04-09 | GSE243725 | GEO
2024-04-09 | GSE243724 | GEO
2020-09-29 | GSE145228 | GEO
2016-01-27 | GSE73624 | GEO
2022-05-01 | GSE186614 | GEO
2015-09-17 | E-GEOD-65918 | biostudies-arrayexpress