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Effect of depletion of LRIG1 on CD8+ tumor infiltrating T cells [CITE-Seq]

ABSTRACT: To investigate the function of LRIG11 in regulating the differentiation of polyclonal CD8 tumor infiltrating T cells during the response to B16melanoma, we isolated CD8 T cells on day 18 post vaccine treatment and examined gene transcription at single cell level

ORGANISM(S): Mus musculus

PROVIDER: GSE245840 | GEO | 2024/01/02

REPOSITORIES: GEO

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Effect of depletion of LRIG1 on polyclonal CD8+ tumor infiltrating T cells and Effect of depletion of LRIG1 on OT1 CD8+ tumor-infiltrating T cells

Project description:To investigate the function of LRIG11 in regulating the differentiation of polyclonal CD8 tumor infiltrating T cells during the response to B16melanoma. And, To investigate the function of LRIG1 in regulating the activaiton of ovalbumin specific OT1 CD8+ T cells during the response to B16 tumor stably expresss ovalbumin as surrogate tumor antigen.

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Effect of depletion of LRIG1 on polyclonal CD8+ tumor infiltrating T cells and Effect of depletion of LRIG1 on OT1 CD8+ tumor-infiltrating T cells

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Effect of depletion of LRIG1 on CD8+ tumor infiltrating T cells

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LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses

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Effect of depletion of LRIG1 on CD8+ tumor infiltrating T cells

Project description:This SuperSeries is composed of the SubSeries listed below.

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