Transcriptomics

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Treatment with cultured epidermal autograft from revertant skin for epidermolytic ichthyosis


ABSTRACT: We performed clinical trial of treatment with cultured epidermal autograft (CEA) produced from patients’ own revertant epidermal keratinocytes as a proof-of-concept study. We successfully produced CEAs from genetically confirmed revertant skin of the three EI patients and genetically confirmed that CEAs mainly consist of revertant wild-type cells by amplicon sequencing and droplet digital PCR analysis. Single-cell RNA sequencing analysis confirmed normal proliferation and safety profiling of CEAs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE245859 | GEO | 2024/05/22

REPOSITORIES: GEO

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