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Transcriptional response of ovarian cancer cell lines to HGF and CDDP

ABSTRACT: HGF sensitizes ovarian cancer cells to chemotherapeutics, e.g. cisplatin (CDDP), through a signaling cascade activated by its MET oncogene encoded receptor and transduced by the p38MAPK. This cascade results in the regulation of a common set of transcripts in three ovarian cancer cell lines, with different genetic profiles and susceptibility to drugs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE24589 | GEO | 2013/12/31

SECONDARY ACCESSION(S): PRJNA133587

REPOSITORIES: GEO

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Transcriptional response of ovarian cancer cell lines to HGF and CDDP

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