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Enhanced CTLA-4 blockade anti-tumor immunity with APG-157 combination in a murine head and neck cancer

ABSTRACT: We evaluated APG-157 and immune checkpoint inhibitors combination treatment using syngeneic mouse head and neck cancer cell line model, SCCVII. The study demonstrated best tumor control with APG-157+ anti-CTLA-4 antibody combination treatment and RNA-seq of the tumor revealed up-regulation of various genes related to T cell activity and down-regulation of various genes related to poor prognosis of head & neck cancer.

ORGANISM(S): Mus musculus

PROVIDER: GSE246084 | GEO | 2023/11/01

REPOSITORIES: GEO

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CTLA-4 blockade induces tumor pyroptosis via CD8+ T cells in head and neck squamous cell carcinoma

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Friends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming

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2011-10-27 | E-GEOD-25093 | biostudies-arrayexpress

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