Transcriptomics

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Tsc1a knockdown and Mycobacterium marinum infection


ABSTRACT: We identify a putative link between miR-126 and the tsc1a signalling pathway resulting in the suppression of permissive macrophage accumulation at early zebrafish-M. marinum granulomas. Mechanistically, we find a detrimental effect of tsc1a expression that renders zebrafish embryos susceptible to higher bacterial burden and increased cell death via mTOR inhibition.

ORGANISM(S): Danio rerio

PROVIDER: GSE246264 | GEO | 2023/10/26

REPOSITORIES: GEO

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