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Improving Thymus Implantation for Congenital Athymia with Interleukin-7

ABSTRACT: Patients receiving thymus implantation develop a functional but incomplete T cell compartment. Our objective was to develop a mouse model to study clinical thymus implantation in congenital athymia and to optimize implantation procedures to maximize T cell education and expansion of naïve T cells. Treating implanted mice with recombinant interleukin (IL-7) promoted homeostatic expansion that improved T cell development, expanded the T cell receptor repertoire, and normalized the naïve T cell compartment.

ORGANISM(S): Mus musculus

PROVIDER: GSE246565 | GEO | 2023/11/29

REPOSITORIES: GEO

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Improving Thymus Implantation for Congenital Athymia with Interleukin-7

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