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Unraveling the Intricate Network of LncRNAs in Corneal Epithelial Wound Healing: Insights into the Regulatory Role of linc17500.

ABSTRACT: The precise role of long non-coding RNAs (lncRNAs) as key epigenetic regulators in mediating corneal epithelial wound healing remains elusive. Here, we aim to elucidate the functional contribution of lncRNAs in regulating CEWH. We used Microarray to characterize lncRNA expression profiling during mouse CEWH. The full thickness of the corneal epithelium of C57BL/6 mice, was removed using a 0.5-mm corneal rust ring remover. Subsequently, the entire corneal epithelium was collected from both the injured and fellow eyes for RNA isolation after approximately 48 hours. Microarray analysis revealed dysregulation of numerous lncRNA candidates during CEWH. Out of the 41,655 non-coding RNAs detected by the microarray, 639 were upregulated and 1,006 were downregulated during the process of CEWH.

ORGANISM(S): Mus musculus

PROVIDER: GSE246761 | GEO | 2024/01/04

REPOSITORIES: GEO

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