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Structural Basis for Cytoplasmic Factors Required for Integrator and CPSF Function

ABSTRACT: The object of this study (or experiment) was to determine the impact of BRAT1 depletion on the transcriptome during differentiation into neuroprogenitor cells. Two control and two BRAT1 knockout H7-human ESC lines were differentiated for 14 days, total RNA isolated and polyA enriched Click-seq libraries generated. Broad transcriptional misregulation was observed between differentiated knockout and control lines. Specifically, the precocious upregulation of several neurogenesis-driving transcription factors indicates the mistiming of differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE246833 | GEO | 2024/07/22

REPOSITORIES: GEO

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