Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bulk RNA-sequencing of synovial macrophages (Fcgr2b-KO mice)

ABSTRACT: Bulk RNA-sequencing of three types of synovial macrophages in Fcgr2b-KO mice stimulated with or without immune complexes

ORGANISM(S): Mus musculus

PROVIDER: GSE247476 | GEO | 2024/09/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Bulk RNA-sequencing of synovial macrophages (wild-type)

Project description:Bulk RNA-sequencing of three types of synovial macrophages in wild-type C57BL/6 mice stimulated with or without immune complexes

2024-09-30 | GSE247475 | GEO

Bulk RNA-sequencing of synovial macrophages (CGRP stimulation)

Project description:Bulk RNA-sequencing of synovial macrophages stimulated with CGRP

2024-09-30 | GSE247477 | GEO

Bulk RNA-sequencing of synovial fibroblasts (IC stimulation)

Project description:Bulk RNA-sequencing of synovial fibroblasts stimulated with IC

2024-09-30 | GSE272541 | GEO

Sequencing of synovial tissue fibroblasts from Rheumatoid Arthritis patients that were co-cultured with inflammatory macrophages.

Project description:The role of synovial tissue fibroblasts and macrophages interactions in driving chronic inflammation and resolution of arthritis is unknown. In this project, we used bulk RNAseq to investigate the impact of different phenotypes of macrophages on activation of synovial fibroblasts.

2020-04-18 | E-MTAB-8316 | biostudies-arrayexpress

Effect of T cell supernatants or cytokines on synovial fibroblasts

Project description:To investigate the effects of soluble factors produced by synovial CD8 T cells, we stimulated human rheumatoid arthritis (RA) synovial fibroblasts with supernatants from synovial fluid CD8 T cells, blood CD8 T cells, or synovial fluid CD4 T cells stimulated with anti-CD3/CD28 antibody-coated beads. For comparison, we stimulated RA synovial fibroblasts with recombinant TNF or interferon-gamma or T cell supernatants pre-incubated with TNF-blocking antibodies.

2022-05-08 | GSE202367 | GEO

Bulk RNA-seq of wild type, HNF4A-knockout (KO), HNF4G-KO, and HNF4A/4G-double KO (DKO) kidney organoids

Project description:We performed bulk RNA-seq and compared complehensive gene expression profiles of kidney organoids induced from wild type, HNF4A-KO, HNF4G-KO, and HNF4A/4G-DKO iPS cell lines.

2023-10-23 | GSE226439 | GEO

Bulk RNA-sequencing on Oryzias latipes WT samples and mespb KO tails 13-14 somite stage

Project description:Bulk-RNA sequencing was performed on WT Cab and mespb KO unsegmented tails at the 13-14 SS (3 replicates each)

2024-03-14 | E-MTAB-13928 | biostudies-arrayexpress

Genome-wide analysis of FcÎ³ receptor ligation on dendritic cells from wild-type, FcÎ³RIIb KO or FcR Î³ chain KO mice

Project description:Analysis of changes in gene expression after incubation of dendritic cells with immune complexes or medium. Since the dendritic cells are derived from three different mouse strains, either wild type, FcÎ³ receptor IIb KO (expresses only activating FcÎ³ receptors) or Fc receptor Î³ chain KO (expresses only inhibitory FcÎ³ receptor), the analysis gives important insight into the roles of the activating versus inhibiting FcÎ³ receptors on dendritic cells. Bone marrow-derived dendritic cells of the three mouse genotypes (see above) were incubated for 4 hours with medium (unstimulated) or OVA-anti OVA immune complexes (IC, stimulated) and changes in gene expression after stimulation with IC were compared between unstimulated vs stimulated with IC and across the three genotypes.

2012-05-02 | E-GEOD-33718 | biostudies-arrayexpress

Expression data from rheumatoid arthritis synovial macrophages

Project description:Macrophages from RA synovial fluids were compared to primary human monocyte-derived macrophages.

2017-08-10 | GSE97779 | GEO

Metabolism in synovial macrophages are reprogrammed by synovial fibroblasts under inflammatory condition

Project description:Macrophages have plasticity to adapt microenvironment. In joint tissue, synovial macrophages (SM) and synovial fibroblasts (SF) are maintained in the homeostasis. In Rheumatoid arthritis, crosstalk between SM and SF via inflammatory response induce abnormal activation in respective cells and contribute to disease progression. However, the activation mechanisms in SM which are encouraged by SF are largely unclear. Here, we demonstrated metabolic reprogramming and immunological activation in SM by secretary stimulations from SF using primary culture synovial cell derived from arthritis model mice. To analyze interaction between SM and SF, primary culture of murine synovial cells was performed, respectively. RNA-seq analysis showed SF express abundant secretion-related gene. Thus, we investigated whether conditioned medium from SF (SF-CM) affects biological activity in SM. As the results, SF-CM condition induced both glycolysis and mitochondrial respiration to SM with increased uptake of glucose and glutamine at least, accompanied with cell survival. In addition, several inflammation markers were also upregulated in SM by SF-CM condition. Taken together, these results suggest that metabolic reprogramming were induced in SM by secretory stimulations from SF, followed by activated inflammatory response and long-live. These indicate that such phenotypes of SM may contribute to chronic inflammation in Rheumatoid arthritis

2020-12-09 | GSE142607 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data