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Methionine availability influences essential H3K36me3 dynamics during cell differentiation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE248199 | GEO | 2023/11/30

REPOSITORIES: GEO

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Methionine availability influences essential H3K36me3 dynamics during cell differentiation.

Project description:Histone modifications are integral to epigenetics through their influence on gene expression and cellular status. While it's established that metabolism, including methionine metabolism, can impact histone methylation, the direct influence of methionine availability on crucial histone marks that determine the epigenomic process remains poorly understood. In this study, we demonstrate that methionine, through its metabolic product, S-adenosylmethionine (SAM), dynamically regulates H3K36me3, a cancer-associated histone modification known to influence cellular status, and myogenic differentiation of mouse myoblast cells. We further demonstrate that the methionine-dependent effects on differentiation are mediated in part through the histone methyltransferase SETD2. Methionine restriction leads to preferential decreases in H3K36me3 abundance and genome accessibility of genes involved in myogenic differentiation. Importantly, the effects of methionine restriction on differentiation and chromatin accessibility can be phenocopied by the deletion of Setd2. Collectively, this study demonstrates that methionine metabolism through its ability to be sensed by chromatin modifying enzymes can have a direct role in influencing cell fate determination.

| S-EPMC10690240 | biostudies-literature

Methionine availability influences essential H3K36me3 dynamics during cell differentiation [ChIP-seq]

Project description:Histone modifications are integral to epigenetics through their influence on gene expression and cellular status. While it's established that metabolism, including methionine metabolism, can impact histone methylation, the direct influence of methionine availability on crucial histone marks that determine the epigenomic process remains poorly understood. In this study, we demonstrate that methionine, through its metabolic product, S-adenosylmethionine (SAM), dynamically regulates H3K36me3, a cancer-associated histone modification known to influence cellular status, and myogenic differentiation of mouse myoblast cells. We further demonstrate that the methionine-dependent effects on differentiation are mediated in part through the histone methyltransferase SETD2, which senses methionine levels. Additionally, methionine restriction leads to preferential decreases in H3K36me3 abundance and genome accessibility of genes involved in myogenic differentiation. Importantly, the effects of methionine restriction on differentiation and chromatin accessibility can be phenocopied by the deletion of Setd2. Collectively, this study demonstrates that methionine metabolism through its ability to be sensed by chromatin modifying enzymes can have a direct role in influencing cell fate determination.

2023-11-30 | GSE248198 | GEO

Methionine availability influences essential H3K36me3 dynamics during cell differentiation [ATAC-seq]

Project description:Histone modifications are integral to epigenetics through their influence on gene expression and cellular status. While it's established that metabolism, including methionine metabolism, can impact histone methylation, the direct influence of methionine availability on crucial histone marks that determine the epigenomic process remains poorly understood. In this study, we demonstrate that methionine, through its metabolic product, S-adenosylmethionine (SAM), dynamically regulates H3K36me3, a cancer-associated histone modification known to influence cellular status, and myogenic differentiation of mouse myoblast cells. We further demonstrate that the methionine-dependent effects on differentiation are mediated in part through the histone methyltransferase SETD2, which senses methionine levels. Additionally, methionine restriction leads to preferential decreases in H3K36me3 abundance and genome accessibility of genes involved in myogenic differentiation. Importantly, the effects of methionine restriction on differentiation and chromatin accessibility can be phenocopied by the deletion of Setd2. Collectively, this study demonstrates that methionine metabolism through its ability to be sensed by chromatin modifying enzymes can have a direct role in influencing cell fate determination.

2023-11-30 | GSE248197 | GEO

Methionine availability influences essential H3K36me3 dynamics during cell differentiation

Project description:Methionine availability influences essential H3K36me3 dynamics during cell differentiation

| PRJNA1042641 | ENA

Methionine availability influences essential H3K36me3 dynamics during cell differentiation [ChIP-seq]

Project description:Methionine availability influences essential H3K36me3 dynamics during cell differentiation [ChIP-seq]

| PRJNA1042644 | ENA

Methionine availability influences essential H3K36me3 dynamics during cell differentiation [ATAC-seq]

Project description:Methionine availability influences essential H3K36me3 dynamics during cell differentiation [ATAC-seq]

| PRJNA1042640 | ENA

Waves of sumoylation support transcription dynamics during adipocyte differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

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Chromatin state dynamics during blood formation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-08 | E-GEOD-60103 | biostudies-arrayexpress

Transcriptional Regulationand Chromatin Dynamics inHuman Epithelial Cell Differentiation

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-04-04 | E-GEOD-64328 | biostudies-arrayexpress

Dynamics and consequences of widespread transcript isoform changes during neuronal differentiation

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