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Single cell gene expression analysis of hematopoietic progenitors in Ddx41-heterozygous mice

ABSTRACT: To determine the effect of heterozygosity of Ddx41 on hematopoiesis, we conducted single cell transcriptome analysis on hematopoietic progenitor cells from Ddx41-heterozygous and control bone marrow. We found that heterozygoisty of Ddx41 did not signficantly alter the distribution of progenitor cell types, and changes in gene expression within the clusters were minimal.

ORGANISM(S): Mus musculus

PROVIDER: GSE248396 | GEO | 2024/06/13

REPOSITORIES: GEO

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DDX41 heterozygosity impairs hematopoietic progenitor cell fitness and cooperates with p53 mutation to drive malignancy [LSK]

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