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Gene expression changes in B-ALL and DLBCL cells induced by EdC, a replication stress-inducing nucleoside analog prodrug.

ABSTRACT: RNA-sequencing analysis of B-ALL and DLBCL cell lines validate the replication stress-inducing mechanism of action (MOA) of EdC. Downregulation of genes involved in cell cycle progression and DNA biosynthesis support initial findings that EdC induces G1/S phase arrest, and upregulation of genes involved in DNA damage response (DDR) and the interferon alpha and gamma response support initial findings that EdC induces DNA damage and apoptosis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE248424 | GEO | 2023/12/08

REPOSITORIES: GEO

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