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Double-negative T cells ameliorate psoriasis by selectively inhibition on IL-17A producing γδ T cells

ABSTRACT: Psoriasis is a chronic immune-mediated skin condition influenced by genetics and environmental factors. γδ T cells, as the main sources of IL-17A, play pivotal roles in the inflammatory processes of psoriasis. During psoriasis pathogenesis, inhibiting the secretion of IL-17A has emerged as a novel therapeutic approach for treating psoriasis. Double-negative T (DNT) cells is a novel type of immunosuppressive cells. Our preliminary research has unveiled that DNT cells play a significant immunoregulatory role in autoimmune and allergic diseases. In this study, we aimed to evaluate the protection of DNT cells and explore its underlying mechanism.

ORGANISM(S): Mus musculus

PROVIDER: GSE248626 | GEO | 2024/04/10

REPOSITORIES: GEO

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