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Transcriptomic and epigenomic profiling of Tet TKO neural stem cells to study NSC specification and multipotency

ABSTRACT: In this study we: (1) identify genes deregulated in wildtype (WT) and Tet triple knockout (TKO) mouse embryonic stem cells (ESC) and neural stem cells (NSC). (2) Profile genome-wide changes in DNA methylation in WT and TKO ESCs and NSCs. (3) Map histone marks H3K4me1 and H3K27ac in WT and TKO ESCs and NSCs. (4) Identify promoter-interacting chromatin loops in WT and TKO NSCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE248933 | GEO | 2024/07/23

REPOSITORIES: GEO

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