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Effect of SMARCA4 knockdown on senescent IMR90 ER:RAS cells

ABSTRACT: We report the analysis of RNA sequencing aimed at understanding the effects induced by the knockdown of various target genes on senescent cells. These genes were initially identified through a genetic screening process designed to locate regulators responsible for upregulating SASP. Specifically, we focus on exploring the repercussions of SMARCA4 knockdown, a constituent of the SWI/SNF complex subunit, on the SASP and immune responses within senescent cells. The findings will help characterise the role of SMARCA4 inhibition on senescence surveillance by Natural Killer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE249064 | GEO | 2024/09/19

REPOSITORIES: GEO

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