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Whole RNA profiling of Tuberculosis-diabetes comorbidity linked to diabetes with poor glycemic control

ABSTRACT: Type 2 diabetes (DM2) is a disease that hinders tuberculosis (TB) control strategies worldwide. TB infection, progression, morbidity, treatment success, adverse effects, relapse, and mortality are worse in these susceptible populations. Therefore, expanding the partially known molecular mechanisms leading to TB-DM2 comorbidity may be essential to face both epidemics. Consequently, a transcriptomic study was conducted on TB-DM2 comorbidity, associated with patients with DM2 who have poor glycaemic control (PDM2), since they have a higher risk of getting TB. Human blood samples from healthy controls (CTRL, HbA1c < 6.5%), TB ( HbA1c < 6.5%), TB-DM2, DM2 (HbA1c < 8.9%), and PDM2 (HbA1c > 10%) groups (n=4 each) were analyzed using high-density human GE 4X44K v2 differential expression microarrays.

ORGANISM(S): Homo sapiens

PROVIDER: GSE249102 | GEO | 2024/06/04

REPOSITORIES: GEO

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Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity

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Whole RNA profiling of Tuberculosis-diabetes comorbidity linked to diabetes with poor glycemic control

Project description:Whole RNA profiling of Tuberculosis-diabetes comorbidity linked to diabetes with poor glycemic control

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Peripheral Blood Monocyte Gene Expression in Recent-Onset Type 1 Diabetes

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Peripheral Blood Monocyte Gene Expression in Recent-Onset Type 1 Diabetes

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Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity

Project description:Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity

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A high glycemic burden drives functional and metabolic alterations of human monocytes in patients with type 1 diabetes

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Expression data from liver of obese (with or without type 2 diabetes) and lean human subjects.

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